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R8K and R8Q are substrate cleft mutations that cause high-level resistance to one of the precursors of ritonavir (A-77003) () but they have not been reported with the current PIs.

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This bioavailability slightly increases if tenofovir is taken with a fat-rich meal.

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Discontinuation of the offending drugs such as antiretrovirals usually leads to recovery, but the defect can be persistent after discontinuation with some agents such as ifosfamide.

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