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R8K and R8Q are substrate cleft mutations that cause high-level resistance to one of the precursors of ritonavir (A-77003) () but they have not been reported with the current PIs.
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This bioavailability slightly increases if tenofovir is taken with a fat-rich meal.
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Duration of time between exposure and seroconversion in healthcare workers with occupationally acquired infection with human immunodeficiency virus.
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Sensitivity of Kaposi's sarcoma-associated herpesvirus replication to antiviral drugs.
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Pregnancy is not a contraindication to hepatitis B vaccination for women who have not previously been vaccinated; current hepatitis B vaccines contain noninfectious HBsAg and should cause no risk to the fetus.
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Notably, using a very sensitive technique (ultra-deep pyrosequencing) viral variants with reduced sensitivity to lamivudine (substitutions in codons 204 and 181) were observed in four women (19%).
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Discontinuation of the offending drugs such as antiretrovirals usually leads to recovery, but the defect can be persistent after discontinuation with some agents such as ifosfamide.
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This study will compare the safety and efficacy of tenofovir alafenamide (TAF) versus tenofovir disoproxil fumarate (TDF) in treatment-naive and treatment-experienced adults with chronic hepatitis B virus (HBV) infection.
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On the basis of controlled trials among children with malignancies, acyclovir is the drug of choice for treating VZV infection in HIV-infected children ( AI).
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